Archive for August, 2009

Questions about breast screening in JNCI as well

Amidst all of the questions about prostate cancer screening today, let’s not lose sight of the Journal of the National Cancer Insititute article on questions about breast exams in the doctor’s office.

The question: do clinical breast exams – docs doing breast exams – improve the accuracy of what mammograms contribute to breast cancer screening?

The implication: The benefit in increased sensitivity from adding clinical breast exams to mammography needs to be weighed against the potential risks and costs of further follow-up due to false-positive results as well as the anxiety associated with additional diagnostic evaluations.

Results: Mammography sensitivity was similar between centers that offered clinical breast exams (CBE) and those that did not. However, women without cancer who were screened at regional cancer centers or affiliated centers that offered clinical breast exams had a higher false-positive rate than women screened at affiliated centers that offered only mammography.

An accompanying editorial concludes:

Low-tech primary care interventions that can decrease the burden of cancer in women are extremely appealing. At the same time, ineffective practices, or those with even marginal net benefit, would be a disservice to our patients. More answers are needed on the role of CBE in breast cancer screening before definitive recommendations for or against its use can be made. While we wait for those answers, the data presented by Chiarelli et al. suggest that CBE must be done well if it is to be done at all, with the acknowledgment that overall referrals and false-positive results will increase.

Watchful waiting OK for many men with prostate cancer

A study in the Journal of Clinical Oncology concludes that, in a nationwide study, more than half the men who opted for “deferred treatment” (another name for watchful waiting) remained without treatment for 7.7 years after diagnosis. Older men and men with lesser cancer severity at diagnosis were more likely to remain untreated. Prostate cancer mortality did not differ between the “deferred treatment” and active treatment patients.

Powerful editorial by Otis Brawley on prostate cancer screening

This week’s Journal of the National Cancer Institute includes a new analysis by Gilbert Welch and Peter Albertsen showing how much overdiagnosis and overtreatment have been the result of 20 years of more aggressive prostate cancer screening.

American Cancer Society chief medical officer Dr. Otis Brawley wrote an accompanying editorial. Excerpts:

In this issue of the Journal, Welch and Albertsen presented information that every man considering prostate cancer screening and treatment should know and understand. Prostate cancer screening has resulted in substantial overdiagnosis and in unnecessary treatment. It may have saved relatively few lives. Results from this article and recent results from prostate cancer screening and prevention trials demand reflection about what we as a society have done and are doing. Lessons to be learned have ethical and economic implications and involve our lack of respect for the scientific process and scientific evidence.

Congresswoman Michele Bachman adds to her fairytale career, ignores international evidence on health care

U.S. Rep. Michele Bachmann (R-Minn.) thinks U.S. health-care system is best in the world, but the statistics say otherwise, reports Casey Selix of Minnpost.com.

Beware when a study misses its primary endpoint and a news release doesn’t even mention that fact

Expect to hear and read a lot of heart research news coming out of Barcelona and the European Society of Cardiology there this week.

Larry Husten on Cardiobrief.org writes about a study missing its primary endpoint, and an academic medical center news release that doesn’t even mention that – even though the drugmakers’ news release actually did prominently feature that fact!

Let me remind you of a study earlier this year by Woloshin & Schwartz and colleagues that concluded:

Press releases from academic medical centers often promote research that has uncertain relevance to human health and do not provide key facts or acknowledge important limitations.

“Money-Driven Medicine” film on Moyers on PBS tonight

The documentary based on Maggie Mahar’s book airs on Bill Moyers Journal on PBS tonight.

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I had the honor of hosting Maggie on the University of Minnesota campus for the world premier showing of the film. I’m pleased to see that the film will get this broader audience on PBS tonight.

CBS promotes John McEnroe as prostate expert without disclosing pharma funding

No surprise. Just another terrible example of the one-sided – potentially harmful – information often disseminated on the network TV morning programs. See the latest review of the CBS Early Show on HealthNewsReview.org

It wraps up a very good week for former tennis star John McEnroe. But not so good for men who may have seen him on TV.

* A prime time appearance on CNN’s Larry King Live promoting prostate cancer screening
* A CBS Early Show appearance promoting prostate cancer screening

And he was getting paid all the time by a drug company – something clearly noted on the website that McEnroe promoted – but something CBS never disclosed on the air.


GlaxoSmithKline funded and helped develop this campaign, including providing compensation to Mr. McEnroe.

CBS merely turned over the network to this drug company sponsored message – a message that has the support of the American Urological Association but that lacks the support of other respected medical organizations such as the American Cancer Society and the US Preventive Services Task Force.

Shameful in its one-sided, imbalanced, incomplete approach, treating McEnroe’s message as gospel.

Scan-happy Americans better wake up to radiation risk

A study in this week’s New England Journal of Medicine looks deeper into the radiation risks from medical imaging scans.

Key quotes on the study in a New York Times story:


“These procedures have a cost, not just in terms of dollars, but in terms of radiation risk,” said the study’s lead author.

“I think the central driver is more about culture than anything else,” co-author Dr. Harlan Krumholz said. “People use imaging instead of examining the patient; they use imaging instead of talking to the patient. Patients should be asking the question: ‘Do I really need this test? Is the information in this test going to help in the decision-making process?’ “

In an editorial accompanying the paper, Dr. Michael S. Lauer, director of prevention and epidemiology at the National Heart, Lung and Blood Institute, called for large clinical trials that would assess whether the scans improve care and lead to better outcomes for patients.

“Were we to insist that all, or nearly all, procedures be studied in well-designed trials, we could answer many critical clinical questions,” Dr. Lauer wrote.

Until then, patients and physicians should discuss the risk of the tests and keep close track of the overall radiation dose that patients are receiving, he wrote, adding, “We have to think and talk explicitly about the elements of danger in exposing our patients to radiation.”

Limping rat provides sciatica insights

A newly developed animal model for the painful nerve condition known as sciatica should help scientists diagnose and treat it, as per Duke University bioengineers and surgeons. Sciatica is not a single disorder, but rather a diverse range of symptoms, such as numbness or pain from the lower back to the feet, radiating leg pain or difficulty in controlling the leg. It is often caused by compression, or pinching, of any of the five nerve roots that combine to make up the sciatic nerve. These roots are the parts of the nerve that pass through openings in the spine to the spinal cord……..

Health care decision-making can be distorted by how risk/benefit data are presented

Two important studies on health care decision-making in the journal PLoS Medicine were nicely summarized by MedPage Today. Excerpts:

How doctors portray clinical risks and benefits — statistically and visually — can influence the decisions patients make about healthcare, and whether those decisions reflect their own values, two randomized studies found. …

One study asked patients whether they would take statins to prevent coronary heart disease (CHD) at a cost of $50 a month, knowing the risks and benefits of taking the drugs.

They found that people were more likely to choose treatment when the data were presented as relative risk reduction — for example, telling patients they would be 30% less likely to develop CHD by taking statins — rather than as absolute summary measures.

However, far more participants believed their understanding of and satisfaction with risk information — and their confidence in their decisions — were greater when natural frequency data were presented.

It seems like every day on HealthNewsReview.org we hammer away at stories that give only relative risk data – not absolute risk data as well. This is really important stuff – as shown in these studies.

The editors of the journal commented:

“It is clear … that there is the potential for shared decision-making to be biased through the adoption of more persuasive presentations — such as relative statistics. As a result, the underlying principle of shared decision-making — that of empowering patients to make decisions most compatible with their values — can be undermined.”